Rashford and Shaw made their return for Manchester United in their Europa League defeat against Sevilla.
United face Brighton in the FA Cup semi-final hoping to secure a place in the final.
Fans have backed Rashford and Shaw to start in the match at Wembley.
Maguire's suspension has worsened United's defensive crisis, with supporters opting to bring Shaw back into a central role.
Malacia and Wan-Bissaka have also been picked to return to the starting line-up.
Bruno Fernandes is expected to lead the team as captain.
Martial is expected to be fit to feature in the match.
Rashford is set to start on the left with Antony on the right.
Fernandes, Casemiro, and Eriksen are expected to start together in midfield.
Rashford is United's top scorer this season with 28 goals.