Kawhi Leonard is out with a sprained right knee, which he aggravated in Game 1 and played through in Game 2.
Leonard's injury is not related to the torn right ACL injury that kept him out all of last season.
Paul George is also sidelined with a sprained right knee and is likely out for the first-round series.
Without Leonard, Norman Powell tried to keep pace with Booker, scoring 42 points in Game 3.
Devin Booker torched the Clippers for 45 points, and Kevin Durant added 28 points, six rebounds and five assists.
The Clippers fell behind 2-1 in the first-round series against the Phoenix Suns after losing 129-124.
Leonard's injury will be monitored and evaluated daily. He is considered day-to-day.
Leonard's injury will not speed up George's return from his injury, which George suffered on March 21.
The Clippers carefully worked Leonard's minutes and workload up all season for exactly this reason.
The Clippers have a quick turnaround before Saturday's 12:30 p.m. PT tipoff for Game 4.